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GRADUATE + LYON St.ETIENNE UNIVERSITIES

Musculo-Skeletal system, Locomotion, Exercise

The overall purpose of the MuSkLE (Musculo-Skeletal system, Locomotion & Exercise) consortium is to set up a network of close to 600 scientists (18 teams and 8 institutes) and clinicians in Saint-Etienne and Lyon specialized in the study of the musculoskeletal system, locomotion and exercise.

MuSkLE aims at identifying the impact of physical exercise, in particular locomotor activities, on the entire musculoskeletal system in different physiological (e.g., athletes, nutrition) and pathophysiological contexts (e.g., osteoporosis, neuromuscular diseases, cancer, inflammatory rheumatism, aging…). Indeed, exercise has been consistently described as a ‘polypill’ to prevent and care multiple diseases but the posology still has to be defined and individualized.

The objective is to break down the borders between fields to propose a true interdisciplinary research on this theme from a molecular to an integrative level, using different models (cell, drosophila, zebrafish, rodent, athlete, patient…).

This original and multi-scale approach (i.e., cellular, tissue, whole organ) will allow to:

  • Improve our understanding of several diseases
  • Study the role of physical exercise and locomotion in their management,
  • Understand the plasticity of this system in response to exercise,
  • Understand the plasticity of this system in response to exercise,

 

The MuSkLE consortium is coordinated by Dr Rémi Mounier and Prof. Vincent Pialoux.

2025-2026: Call for Excellence Scholarships
1st year of Master

We are pleased to announce the launching of the Excellence Scholarship Campaign for Masters students who wish to attend the master 1 of the MuSkLE Graduate Programme.

  • Submissions open: April 2nd, 2025
  • Deadline for applications: June 3rd 2025

2025-2026: Call for Excellence Scholarships
2nd year of Master

We are pleased to announce the launching of the Excellence Scholarship Campaign for Masters students who wish to attend one of the masters 2 of the MuSkLE Graduate Programme.

  • Submissions open: April 2nd, 2025
  • Deadline for applications: June 3rd 2025
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2025-2028: Call for Excellence Doctoral Scholarship InnovInOnco/MuSkLE

The Lyon1 University is very proud to announce scholarships in support of excellent students who wish to complete their PhD in France, in an interdisciplinary doctoral program dedicated to link Oncology and the musculoskeletal system. Scholarships are supported by the Graduate initiative InnovInOnco and MuSkLE within the Graduate + framework.

  • Deadline: May 04, 2025

MuSkLE: Summer school

Save the date: from June 01 to June 06, 2025

We welcome Bachelor (in priority) and Master students in molecular biology, cell biology, medicine, physiotherapy, physiology and exercise science interested in research on the musculo-skeletal system.

Application dealine: January 13, 2025

Internship offers

MUSKLE: Research Internship - M2

Ultrasound assessment of the humeral head translation during maximal voluntary contraction of rotator cuff and periscapular muscles

Laboratory: Laboratoire Interuniversitaire de Biologie de la Motricité – UR 7424
Research team: Sport Performance and Injury Prevention

MUSKLE: Research Internship - M2

Functional effects of a TRPV1 mutation associated with exertional heat stroke

Laboratory: CarMeN Laboratory
Research team: IRIS Team- Ischemia-Reperfusion Injury Syndrome

MUSKLE: Research Internship - M2

Development of iPSC-Derived Cellular Models from Patients with Spinal Muscular Atrophy and In Vitro Phenotypic Characterization Using iPSC-Derived Cells

Laboratory: : Institut NeuroMyoGène, Laboratoire Physiopathologie et Génétique du Neurone et du Muscle
Research team: Equipe Schaeffer

MUSKLE: Research Internship - M2

Interaction between acute physical exercise and anticancer treatment on tumoral microenvironment in mice models of colorectal cancer

Laboratory: Laboratoire Interuniversitaire de Biologie de la Motricité, UR7424
Research team: Team Atherosclerosis, Thrombosis and Physical Activity

MUSKLE: Research Internship - M2

Molecular regulation of protein transport in skeletal muscle

Laboratory : Institut Neuromyogene -Physiopathology of Neuron and Muscle (PGNM)
Research team: Muscle Nuclear & Cytoskeleton Architecture (MNCA)

MUSKLE: Research Internship - M2

Role of TGF-beta signalling in connective tissue precursors for skeletal muscle patterning

Laboratory: Institut de Génomique Fonctionnelle de Lyon (IGFL / ENS Lyon)
Research team: “Developmental and Evolutionary Histories of Vertebrates” (DEHV)

MUSKLE: Research Internship - M2

Interaction of physical activity and sleep apnea on the biological markers of carotid plaque rupture

Laboratory: Laboratoire Interuniversitaire de Biologie de la Motricité, UR7424,
Research team: Team Atherosclerosis, Thrombosis and Physical Activity

MUSKLE: Research Internship - M2

Validation of a markerless system for assessing jump biomechanics

Laboratory: Laboratoire Interuniversitaire de Biologie de la Motricité
Research team: Sport Performance and Injury Prevention, SPIP

MUSKLE: Research Internship - M2

Investigating the implication of a new gene in Hereditary Sensory and Autonomic Neuropathies Using Induced Pluripotent Stem Cell (iPSC)-Derived Models

Laboratory: Institut NeuroMyoGène, Laboratoire Physiopathologie et Génétique du Neurone et du Muscle
Research team: Equipe Schaeffer

MUSKLE: Research Internship - M2

Myonuclear adaptations to contractile activity

Laboratory: Institut NeuroMyoGène - Physiopathologie et Génétique du Neurone et du Muscle (PGNM)
Research team: Stem cell environment and skeletal muscle homeostasis

MUSKLE: Research Internship - M2

Cardiovasculaire, Métabolisme, Diabétologie et Nutrition

Laboratories: Laboratoire de Recherche CarMeN UMR INSERM-INRAe, Université Lyon 1

MUSKLE: Research Internship - M2

Deciphering the microtubule network re-organization during muscle fiber formation using “Live-SuperResolution Microscopy” in healthy and pathological conditions

Laboratory: Pathophysiology and genetics of neuron and muscle (PGNM)
Research team: Muscle Nuclear & Cytoskeleton Architecture (MNCA)

MUSKLE: Research Internship - M2

Studying the pathophysiological mechanisms of Bethlem myopathy using zebrafish model

Laboratory: Institut de Génomique Fonctionnelle de Lyon (IGFL / ENS Lyon), CNRS UMR 5242
Research team: Florence Ruggiero

MUSKLE: Research Internship - M2

Building and maintaining the architecture of the locomotor system: from genes to function

Laboratories: Institut de Génomique Fonctionnelle de Lyon
Research team: fonction et développement du système neuromusculaire

MUSKLE: Research Internship - M2

Role of TGF-beta signalling in connective tissue precursors for skeletal muscle patterning

Laboratory: Institut de Génomique Fonctionnelle de Lyon (IGFL / ENS Lyon), CNRS UMR 5242
Research team: “Developmental and Evolutionary Histories of Vertebrates” (DEHV)

Fields

Musculo-Skeletal system

Biology

Biomechanics

Health

Kinesiology

Medicine

Physiology

A Programme from Master to PhD

Upon entering the Graduate+ Initiatives Master programme, students will work closely with faculty and researchers to build their academic project. Each student will be assigned an academic advisor and will be actively involved in research activities throughout the programme.

  • MASTER
  • DOCTORAL SCHOOLS
  • RESEARCH

Select from one of our Master's programmes and map out your own academic journey. You can customise your path according to your interests and objectives with a diverse range of Master's options.

 

Master in Integrative Biology and Physiology

 

STAPS Master's: Training and Optimization of Sports Performance

 

Master in Mechanical Engineering

 

Master in Health Engineering

Doctoral research is conducted in a partner laboratory at Graduate +. The training takes place in a doctoral school.

 

Associated doctoral schools:

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